Effects of a carbonic anhydrase inhibitor on cerebral blood flow in geriatric patients.

نویسندگان

  • D J Wyper
  • C J McAlpine
  • K Jawad
  • B Jennett
چکیده

A carbonic anhydrase inhibitor (UK-12,130) was shown to increase cerebral blood flow in mildly demented geriatric patients. Oral administration caused a significant increase in blood flow at two different dose levels; this persisted for at least six weeks, which was the duration of the longest study. There was no consistent improvement in mentation during treatment. Blood blow was measured by the washout of 133Xe after inhalation of this inert gas.

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عنوان ژورنال:
  • Journal of neurology, neurosurgery, and psychiatry

دوره 39 9  شماره 

صفحات  -

تاریخ انتشار 1976